After the world's population has been ravaged by a pandemic, a man lives a lonesome existence in a Colorado airplane hangar with his dog and a dour gunman he has befriended. When a mysterious transmission comes through on the radio while he’s flying his old Cessna, it sparks a hunt for the provenance of the sound.

After a mysterious cosmic event rips Oak Street from suburbia and transports their neighborhood to someplace unknown, a family soon discovers that their very survival depends on them sticking together as they navigate their now unrecognizable surroundings.